gastro retentive drug delivery systems: a review
نویسندگان
چکیده
gastric emptying is a complex and extremely variable process. this causes the unpredictability of the bioavailability of drug delivery systems. gastro retentive drug delivery systems (grdds)s have received significant interest in the past decades as they can overcome the limitation of conventional oral controlled release drug delivery systems related to fast gastric emptying time. an optimum grdds can be defined as a system which remains in the stomach for a sufficient time interval and releases active ingredients in a controlled manner. this, significantly extends the duration of drug release, prolongs dosing interval and increases bioavailability of drugs and therefore improves compliance of the patients and effectiveness of pharmacotherapy. this article gives an overview of the main concepts used to design pharmaceutical dosage forms with prolonged gastric residence times as well as the parameters effecting gastric emptying, advantages , shortcomings, formulation considerations and, factors effecting gastro retentive systems. the main emphasis is on the entire classification and different types of grddss. finally evaluation methods of these systems have been summarized.
منابع مشابه
Design of Gastro Retentive Drug Delivery System of Diltiazem Hydrochloride
L. K. Omray Ravishankar College of Pharmacy, Bhopal E.mail: [email protected] Abstract Gastro retentive drug delivery system of diltiazem hydrochloride was designed and evaluated for its effectiveness for the management of mild to moderate hypertension. Gastro retentive drug delivery system were prepared using polyvinyl alcohol and sodium carboxy methyl cellulose as the polymers and sodium...
متن کاملZero-order delivery of a highly soluble, low dose drug alfuzosin hydrochloride via gastro-retentive system.
A composite gastro-retentive matrix for zero-order delivery of highly soluble drug alfuzosin hydrochloride (10mg) has been designed and characterized. Two systems containing polyethylene oxide (PEO), hydroxypropylmethylcellulose (HPMC), sodium bicarbonate, citric acid and polyvinyl pyrrolidone were dry blended and compressed into triple layer and bi-layer composite matrices. Dissolution studies...
متن کاملFormulation Development and Evaluation of Gastro Retentive Floating Drug Delivery System for Novel Fluoroquinolone using Natural and Semisynthetic Polymers
The purpose of present research work is to develop gastro retentive formulation for Moxifloxacin using various release retardants. Moxifloxacin, novel synthetic fluoro quinolone, antibacterial agent. Floating tablets of Moxifloxacin. HCl were prepared using variable amounts of HPMCK4M, HPMCK15M and HPMCK100M with effervescent mixtures by direct compression technique. Totally 9 formulations were...
متن کاملHydrodynamically Balanced Gastro-Retentive Site Specific Drug Delivery System: An Innovative Approach
Conventional oral dosage forms suffer with many disadvantages. To avoid such limitations controlled release dosage forms are preferred. When these controlled release dosage forms administered by oral route retained in the stomach and release the drug in a controlled fashion continuously in gastrointestinal tract [1]. Controlled release systems also suffer with some limitations such as short gas...
متن کاملNano-gels: A versatile nano -carrier platform for drug delivery systems: A mini review
Nowadays the application of nanotechnology in different biomedical fields such as drug delivery is increasing due to its unique advantages. With this in mind, it is widely believed that nanogels as the nanometer-sized networked polymeric particles have a considerable impact on drug delivery systems as biocompatible nanocarriers due to their unique characteristics such as high loading capacity, ...
متن کاملمنابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
journal of reports in pharmaceutical sciencesجلد ۲، شماره ۲، صفحات ۱۹۰-۲۰۴
میزبانی شده توسط پلتفرم ابری doprax.com
copyright © 2015-2023